For Barrett's esophagitis with a symptomatic reflux that persists despite potent antacids, H-2 blockers or omeprazole, some medical centers are now investigating antireflux surgery, which may help control symptoms and prevent chronic reflux. Whether this will prevent cancer has not been proven. In patients with progressive Barrett's esophagus who have abnormal changes in the cells that indicate cancer might develop (mucosal dysplasia), the esophagus may be removed as a prophylactic measure.